Semaglutide, tirzepatide, and retatrutide represent three generations of obesity medications. Here’s how GLP-1, dual-agonist, and triple-agonist therapies compare for weight loss, metabolism, and future obesity treatment.
Retatrutide is an investigational triple-agonist weight loss injection targeting GLP-1, GIP, and glucagon receptors simultaneously. Early trials suggest it may outperform current obesity medications, including Wegovy and Mounjaro.
Retatrutide may become the next major breakthrough in obesity medicine. Here’s how the investigational triple-agonist compares with Wegovy, Mounjaro, and other GLP-1 medications for weight loss and metabolic health.